Rumination <\/strong>= repeated regurgitation of foods<\/li>\n<\/ul>\nClinical Descriptions of Eating Disorders I. Anorexia Nervosa <\/strong>(AN) DMS-5 Criteria:<\/p>\n1) Restriction of food that leads to very low body weight; body weight is significantly below normal<\/p>\n
BMI less than 18.5) o Weight loss achieved through dieting and perhaps purging and excessive exercise<\/p>\n
2) Intense fear of weight gain\/being fat or repeated behaviours that interfere with weight gain *fear not reduced by weight loss<\/p>\n
3) Body image disturbance *distorted body image or sense of body shape o Particularly the abdomen, hips, thighs are too fat<\/p>\n
\n- \n
\n- Weight themselves frequently, measure themselves, gaze in the mirror critically o Often assessed via questionnaire<\/li>\n
- Women ideal: very thin (compared to normal), overestimate their own size, Male ideal: same as normal, overestimate their own size<\/li>\n<\/ul>\n<\/li>\n
- SEVERITY: (BMI) Mild<\/strong> = =\/< 17, Moderate<\/strong> = 16-16.99, Severe<\/strong> = 15-15.99, Extreme<\/strong> = <15 o Healthy BMI is between 20-25<\/li>\n
- Amenorrhea<\/strong> = loss of menstrual period, is no longer a criteria<\/li>\n
- Term anorexia<\/strong> refers to loss of appetite, nervosa<\/strong> indicates loss is due to emotional reasons<\/li>\n<\/ul>\n
\uf0b7 2 subtypes:<\/p>\n
o\u00a0 \u00a01) Restricting type: weight loss is achieved by severely restricting food intake<\/p>\n
\n- \n
\n- 2) Binge eating\/purging: person has also regularly engaged in binge eating and purging\n
\n- Nearly 2\/3 who meet category 1, switched over to 2 eight years later<\/li>\n<\/ul>\n<\/li>\n
- Typically begins in middle teenage years, often after episode of dieting an occurrence of life stress<\/li>\n
- Prevalence: less than 1% (stable), 10x as frequent in women as men *greater cultural emphasis on women\u2019s beauty o Higher mortality from men with disorder than women<\/li>\n
- Comorbid with: depression, OCD, specific phobia, panic disorder and personality disorders \uf0b7 High suicide rates: 5% complete, 20% attempt Physical Consequences<\/li>\n
- Low blood pressure, slow heart rate, kidney\/gastrointestinal problems, bone mass declines, skin dries, brittle nails, mild anemia<\/li>\n
- Lanugo<\/strong> = fine, soft hair, loss of hair from scalp<\/li>\n
- Loss of Na and K electrolytes \uf0e0 tiredness, weakness, cardiac arrhythmias, sudden death<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n
Prognosis<\/p>\n
\n- 50-70% eventually recover, often after 6-7 years, common relapses before<\/li>\n
- Death rates are 10x higher than the general population, 2x as high as those with other psyc disorders<\/li>\n
- 3-5% mortality rates among women *most often from physical complications (heart failure) and suicide o Death most likely among those who have had it for the longest Bulimia Nervosa <\/strong>(BN)<\/li>\n<\/ul>\n
DSM-5 Criteria<\/p>\n
\n- 1) Recurrent episodes of binge eating o Eating an excessive amount of food within a short period of time\n
\n- Accompanied by feeling of losing control over eating \u2013 feel like one cannot stop<\/li>\n<\/ul>\n<\/li>\n
- 2) Recurrent compensatory behaviour to prevent weight gain, for example, vomiting<\/li>\n
- 3) Body shape and weight are extremely important for self-evaluation<\/li>\n<\/ul>\n
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Bulimia<\/strong> comes from a Greek word for ox hunger \u2013 rapid consumption of a large amount of food<\/p>\n\n- People with bulimia are distinct from anorexia because they do not lose an excessive amount of weight<\/li>\n
- Binges occur in secret, triggered by stress and negative emotions they arouse, continue until uncomfortably full o Often involves soft, sweet foods that can be rapidly consumed: ice cream, cake o More likely to binge while alone, during morning\/afternoon o Avoiding a craved food can lead to a binge the next day o Likely to occur after negative social interaction<\/li>\n
- Severity: (Compensatory behaviours) Mild<\/strong> = 1-3\/week, Moderate<\/strong> = 4-7\/week, Severe<\/strong> = 8-13\/week, Extreme<\/strong> = 14+\/week<\/li>\n
- Must occur at least once a week for 3 months<\/li>\n
- Self-esteem depends heavily on maintaining normal weight<\/li>\n
- More accurate than normal population in reporting height\/weight<\/li>\n
- DSM-IV-TR included subtypes which were removed<\/li>\n
- Begins in late adolescence\/early adulthood, 90% are women, 1-2% prevalence among females<\/li>\n
- Many are somewhat overweight before onset<\/li>\n
- Comorbid with: depression, personality disorders, anxiety disorders, substance use disorders, conduct disorder o Increase likelihood in both directions, except bulimia usually precedes substance use disorders<\/li>\n
- Higher suicide rates than normal population (lower than anorexia)<\/li>\n<\/ul>\n
Physical Consequences<\/p>\n
\n- Typically have a normal BMI but amenorrhea can still occur<\/li>\n
- Frequent purging can lead to K depletion, loss of electrolytes, irregular heartbeat<\/li>\n
- Vomiting can lead to tearing of stomach tissue and throat tissue, loss of dental enamel \uf0b7 Swollen salivary glands<\/li>\n
- Mortality rate of 4% for women<\/li>\n<\/ul>\n
Prognosis<\/p>\n
\n- Close to75% recover, 10-20% remain fully symptomatic<\/li>\n
- Earlier intervention linked to better prognosis Binge Eating Disorder <\/strong>(BED) DSM-5 Criteria:<\/li>\n
- 1) Recurrent binge eating episodes o 1+\/week for 3 months<\/li>\n
- 2) Binge eating episodes include at least 3 of the following:\n
\n- Eating more quickly than usual, eating until over full, eating large amounts even if not hungry, eating alone due to embarrassment about large food quantity, feeling bad after binge<\/li>\n<\/ul>\n<\/li>\n
- 3) No compensatory behaviour is present<\/li>\n
- Most often are obese (BMI greater than 30), prevalence among 2-25% of obese people o Many have a history of dieting<\/li>\n
- Severity (# binges\/week): Mild<\/strong> 1-3\/week, Moderate<\/strong> = 4-7\/week, Severe<\/strong> = 8-13, Extreme<\/strong> = 14+\/week<\/li>\n
- Comorbid with: mood disorders, anxiety disorders, ADHD, conduct disorder, substance use disorder<\/li>\n
- Risk factors: childhood obesity, critical comments about being overweight, weight-loss attempts in childhood, low self-concept, depression, and childhood abuse<\/li>\n
- More prevalent than other eating disorders, 0.2-4.7% prevalence, more common in women (less gender difference)<\/li>\n
- Equally prevalent cross-culturally<\/li>\n<\/ul>\n
Physical Consequences<\/p>\n
\n- Increased risk of type II diabetes, cardiovascular problems, chronic back pain, headaches \uf0b7 Sleep problems, anxiety, depression, IBS, early onset menstruation for women<\/li>\n<\/ul>\n
Prognosis<\/p>\n
\n- 25-82% of people recover<\/li>\n
- Lasts approximately 14.4 years (longer than anorexia\/bulimia) or just over 4 years? Etiology of Eating Disorders<\/strong><\/li>\n<\/ul>\n
Genetic Factors<\/p>\n
\n- Unlikely caused by 1 gene, although they do run in the family<\/li>\n
- 1st<\/sup> degree relatives of women with anorexia are 10x more likely to have the disorder, 4x for bulimia o Same for men with anorexia, but not bulimia<\/li>\n
- Higher MZ than DZ concordance rates for anorexia and bulimia<\/li>\n
- Environmental factors are also very important (higher proportion of bulimia due to environmental than genetic factors)<\/li>\n
- Heritable: dissatisfaction with one\u2019s body, strong desire to be thin, binge eating, preoccupation with weight<\/li>\n
- Genetic factors may link to negative emotionality and constraint with eating disorders<\/li>\n<\/ul>\n
Neurobiological Factors<\/p>\n
\n- Hypothalamus is a key brain structure involved in regulating hunger *not dysfunctional in anorexia<\/li>\n
- Endogenous opioids reduce pain sensations, enhance mood and suppress appetite o Released during starvation, related to anorexia, bulimia and BED **increased levels o Excessive exercise increases opioids *reinforcing<\/li>\n
- Low levels of beta-endorphin in bulimia *not sure if this is a cause or effect<\/li>\n
- Serotonin \u2013 related to eating and satiety (feeling full) *promotes satiety o Binges could result from serotonin deficit o Food restriction interferes with serotonin synthesis\n
\n- Low levels of serotonin metabolites in AN and BN = underactive NTM activity o Show poor response to 5-HT agonists in AN if haven\u2019t been restored to healthy weight o Linked to comorbid depression<\/li>\n<\/ul>\n<\/li>\n
- Dopamine \u2013 related to reward\/pleasure aspects of food o Linked to motivation to obtain food o Restrained eaters more sensitive to food cues o Ventral striatum linked to DA level and reward<\/li>\n<\/ul>\n
\uf0a7 More activated in people with AN when looking at images of thin women o People with AN or BN show greater expression of DA transported gene DAT o Bingeing on sucrose leads to increased release of DA in the striatum<\/p>\n
Cognitive-Behavioural Factors<\/p>\n
\n- Focus on distorted body image, fear of fat, loss of control of over eating \uf0b7 Anorexia Nervosa:\n
\n- Emphasis on fear of fatness and body image disturbance as motivating factor that reinforced weight loss<\/li>\n
- Onset often follows a period of weight loss and dieting<\/li>\n
- Behaviours to achieve thinness are negatively reinforced by reduction of anxiety about becoming fat\n
\n- Positively reinforced by comments form others o Dieting and weight loss positively reinforced by sense of mastery or self-control o Perfectionism and sense of personal inadequacy may lead a person to become concerned with appearance<\/li>\n
- Compare oneself to portrayals in media of thin ideal, being overweight and comparing to attractive others all lead to greater dissatisfaction in one\u2019s body image<\/li>\n<\/ul>\n<\/li>\n
- Criticism from peers and parents about being overweight<\/li>\n
- Experience many negative emotions but also positive emotions (e.g. pride) after losing weight or avoiding treats\n
\n- Low positive emotion differentiation: may confuse this feeling with happiness or success<\/li>\n
- Low positive emotion differentiation predicts eating disorder behaviours (same with high negative) \uf0b7 Bulimia Nervosa and BED:<\/li>\n<\/ul>\n<\/li>\n
- View self-worth in terms of body weight and shape<\/li>\n
- Low self-esteem, hope control over body will help feel better generally o Try to follow strict eating plan, rules are inevitably broken, escalates into binge o Feelings of disgust and fear build up after binge, leading to compensatory actions o Purging temporarily reduces anxiety but lowers self-esteem, and cycle repeats\n
\n- Low SE and high negative affect \uf0e0 Dieting to feel better about self \uf0e0 Food intake restricted too severely \uf0e0 Diet is broken \uf0e0 Binge \uf0e0 Compensatory behaviours to reduce fear of weight gain<\/li>\n<\/ul>\n<\/li>\n
- Restraint scale<\/strong> \u2013 questionnaire measure of concerns about dieting and overeating o Bingeing helps regulate amount of negative affect, although tend to experience more negative affect after binge<\/li>\n
- Purging is reinforced by decreasing negative affect<\/li>\n
- Concerns about body shape and weight predict restrained eating, which predicts increased bingeing<\/li>\n
- Attention, memory and problem solving are affected with eating disorders\n